Before you can fix the problem, you must understand the hardware component you are dealing with. The code "PNP0500" is a Hardware ID (HWID) used by the Advanced Configuration and Power Interface (ACPI).
Modern versions support low-power states when the port is not in use.
Many users encounter the -pnp0500 error after plugging in a cheap USB-to-Serial adapter (using Prolific PL2303 or CH340 chips). If this is your scenario:
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