Historically, U4.exe appears as a component of (versions 16 and 17) or Snappy Driver Installer . In this context, "U4" stands for "Universal driver Update" or a specific index file for USB and chipset drivers.
If you ignored the warnings and downloaded U4.exe from a suspicious source (e.g., a popup saying "Your U4 driver is outdated"), you may have malware. Symptoms include: Download U4.exe
The file is the main executable used to launch Uncharted 4: A Thief's End as part of the Uncharted: Legacy of Thieves Collection on PC. Historically, U4