: Mount the downloaded ISO to the VM's virtual optical drive.
For a genuine MS-DOS 6.22 bootable ISO, common checksums are (check the site for exact values): download ms dos 6.22 bootable iso
– Works perfectly in VirtualBox, VMware, or 86Box (for accuracy). The ISO mounts directly. : Mount the downloaded ISO to the VM's virtual optical drive
If you have the original files or want to create a bootable USB drive instead of a CD/ISO, several modern tools can help: How to create a Bootable DOS or MS-DOS USB Drive download ms dos 6.22 bootable iso