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The most common cause of Error Code 501 is a corrupted installation database or leftover files from a previous version of the app. Even if you think you uninstalled the app, "ghost files" can remain and conflict with the new installation.

Open (located in Applications > Utilities ).

: If you don't want to restart, open Activity Monitor (Cmd + Space, then type "Activity Monitor") and "Force Quit" any process related to Adobe, such as: Creative Cloud CCXProcess