MIB-3 is a monoclonal antibody designed to detect the Ki-67 antigen , a protein present in the nucleus of cells that are actively dividing. It was developed to work on paraffin-embedded tissue samples, which are the standard for long-term hospital storage. This was a major breakthrough because original Ki-67 tests only worked on fresh or frozen tissue, making them difficult to use in routine clinical settings. The Role of Ki-67 in Cell Division
Because it is absent during the "resting" phase (G0), the amount of MIB-3 staining in a sample tells doctors exactly what percentage of the tumor is currently multiplying. Clinical Applications and Prognosis m.i.b 3
MIB-3 is a monoclonal antibody designed to detect the Ki-67 antigen , a protein present in the nucleus of cells that are actively dividing. It was developed to work on paraffin-embedded tissue samples, which are the standard for long-term hospital storage. This was a major breakthrough because original Ki-67 tests only worked on fresh or frozen tissue, making them difficult to use in routine clinical settings. The Role of Ki-67 in Cell Division
Because it is absent during the "resting" phase (G0), the amount of MIB-3 staining in a sample tells doctors exactly what percentage of the tumor is currently multiplying. Clinical Applications and Prognosis