Total Overdose was originally released on the PlayStation 2, Xbox, and PC. There was no official PlayStation Portable (PSP) version released to the public. However, the PS2 version of the game is relatively lightweight in terms of file size.

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The PSP version is slightly trimmed down compared to the PC/PS2 versions, but it retains the core gameplay loop and all the "loco" moves, making it perfect for mobile sessions.