Some security tools (Windows Defender, Bitdefender, Malwarebytes) block XMBC from writing settings. Disable them briefly to test. If the error disappears, add XMBC as an allowed app.
Reinstalling the application can help resolve issues related to corrupted files or incorrect installation. X Mouse Button Control Unable To Save The Settings File
If you are receiving an "Unable to save the settings file" error in X-Mouse Button Control (XMBC), it is usually caused by restricted folder permissions, a missing directory, or an outdated version of the software . Some security tools (Windows Defender
: Right-click the folder, select Properties , go to the Security tab, and ensure your user account has "Full control" or "Write" permissions. a missing directory
C:\Users\<YourUsername>\AppData\Roaming\Highresolution Enterprises\XMouseButtonControl
If the key is severely corrupt, deleting it forces XMBC to create a fresh one on next launch.