While SAI 2 is not free, it is a one-time purchase (approx. $50 USD). You buy it, you own it forever. No monthly fees.
Support for up to 100,000 x 100,000 pixels.
Every other program touts "Vector layers" where you can manipulate nodes. SAI 2 has them, but nobody uses them for nodes. Instead, SAI 2 introduced a hybrid layer type: .
"I can't find the bucket fill tool." Fix: It is called the "Flood fill" tool (Bucket icon). By default, it only fills the current layer. Check "Target" > "Layer" to fill transparent areas.
Here is everything you need to know about why this software is a staple in the industry and how to make the most of it. What is Paint Tool SAI 2?