Set "Pages per sheet" to 2 (2-up). Set "Binding" to "Left Edge" (or Top for landscape books). Verify that "Auto-rotate pages to fit" is checked.
While Adobe Acrobat and standard PDF readers offer basic printing capabilities, they lack the nuance required for professional booklet printing, N-up layouts, or step-and-repeat patterns. This is where specialized software steps in, and for over a decade, one name has stood out for standalone utility: . Imposition Wizard 3.5.3