RTSS relies on Microsoft Visual C++ packages. If these are broken, the won't launch. Download the All-in-One Visual C++ Redistributable package from a reputable source like TechPowerUp.
The "AFR" utility is designed to run preliminary checks the first time you launch an Autodesk program after installation. It verifies your licensing status, checks for software updates, and configures user profile settings. The "x64" simply denotes that it is the 64-bit version of the application, compatible with modern Windows operating systems. afr-x64.exe application error