Even harder. Windows 10 blocks 16-bit apps entirely. Use the Virtual PC method described here or upgrade to PageMaker 7.0.
Many retro executables are falsely flagged. Upload the file to VirusTotal.com . If only 1–2 obscure engines alert, it’s safe. If 10+ detect, delete it and find a cleaner source. Pagemaker 5.0 Free- Download Windows 7 64 Bit