Most modern PS3 games exceed 4GB. If you try to copy a 20GB ISO to a FAT32 USB drive, Windows will fail.
PS3_ISO_Tools.exe --extract "E:\BACKUPS\BLES12345.ISO" --out "F:\JB" ps3 iso tools 4.89
: If you downloaded an ISO from the web, it may be encrypted. You can use tools like 3k3y ISO Tools or PS3Dec along with the correct dkey to decrypt them before they will work on your console. Most modern PS3 games exceed 4GB