If the error message includes "File system error (-2147219196)", it may indicate a broken file association. Resetting default app settings can help.
This is the most common cause. If the TWAIN or WIA drivers that allow Windows to communicate with the Epson scanner become corrupted (due to a power surge, improper shutdown, or disk error), Es2utility.exe tries to call upon them and fails, resulting in a system error. Es2utility.exe System Error
